Harry Monk:
I’ve tried running at different motorway speeds from 50 to 56 mph, it makes no difference whatsoever, I assume any decrease in aerodynamic drag in running slower is cancelled out by the engine running at a less efficient rpm.
From what you say Harry, you should get your intercooler pressure tested, if there are any leaks, throw it in the skip and if it hasn’t been done recently get the valves set
If you’ve slowed down 6mph you should’ve seen a half mpg improvement, fuel use is pure physics and there are only four factors in it.
One. Aerodynamic drag, more speed, more drag, more fuel needed to vercome it. Less speed, less drag, less fuel needed.
Two. Rolling resistance, the more resistance from tyres and weight, the more fuel needed to overcome it.
Three. Mechanical resistance, friction in the moving parts of the lorry/trailer, from the engine to the wheel bearings, lower this, by using synthetic lubes for example and you’ll see a fuel saving. Wheel alignment can make a difference here too and it will also affect the rolling resistance to a degree too.
Four. Thermal efficiency, if your engine has a leaky intercooler, valves out of adjustment, poor airflow in and out (air filter or exhaust restriction) then the thermal efficiency of the engine will be compromised, so it pays to have everything in tip top condition.
If all of the above is in order, speed is the biggest factor in mpg as it affects all of the above, forget about sweet spots and all that, the sweet spot of an engine is only a sweet spot compared to the rest of the RPM range when the engine is under full load and if you’ve got the engine at full load all day long, well you ain’t going to be getting any kind of economy out of it 
Momentum is the key to getting the best mpg, anticipation and forward planning to ensure you keep rolling with the minimum of throttle input is how to reduce mpg. Treat the throttle pedal as if it is going to cut your feet and be very gentle with it. Only use cruise control on level roads and never use the resume function, it has only one goal and that is to bring the lorry up to its set speed asap, you can coax it up on the throttle in almost the same time and use less fuel. On an undulating road let momentum help you along, so what if it drops back a few mph before you crest the hill, you’ll be back up to speed for free on the other side. You’ll not only save fuel doing this, you’ll feel more relaxed and as you’re actually driving as opposed to attending the steering wheel, the time passes quicker too 
However, all of this is secondary to the most important thing in improving mpg, that is to keep accurate records for each tank and work out daily/weekly/monthly averages, as soon as you start to do this your mpg will improve as you’ll try to beat your previous numbers, to the point where some will become obsessed with it 