Having done many long trips by truck car and motorbike but I prefer the latter although it is the most uncomfortable it is certainly the most exhilarating. Several Swiss mountain passes in one day certainly keeps you mind focused on the road rather than you aching rear end etc.
Regarding trucks and cars I think it depends on the quality of the vehicle. eg 400 miles in a 60’s or 70’s truck is a little different to 400 miles in a modern truck.
Same as 400 miles in a basic cost car is a little different to a sumptuous luxury car.
I used to enjoy long distance in my younger days but now I am glad these days are over. Surprisingly enough I can’t be doing with all the moronic drivers that are around. 